PDX Model Market

PDX model market is anticipated to grow at a CAGR of 16.1% during forecast period and estimated to reach USD 403 million by 2028.

PDX Model Market Overview

The patient-derived xenografts (PDX) models are an effective tool in the biomedical research field in which the cancerous tumor or cells from the patients are transferred or implanted into immunodeficient rodents like mice or rats. They are developed for cancer research based on expectations that these models have the capability to retain the tumor characteristics, particularly for the patient-derived orthotropic xenograft. Basically, these models include the uninterrupted transfer of human disease samples into mice.

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Major PDX Model Market Drivers

The PDX market is projected to witness a smooth growth curve over the forecast period, owing to the increasing number of research and development activities to increase the treatment options and rising demand for personalized medicines. In addition, with the rising incidences of cancer, the need to develop better treatment options has increased, which is thereby driving the market growth. As per the World Cancer Research Fund, in 2018, there were nearly 18 million cases of cancer worldwide. Thus, rising support for cancer research from the public and the private sector in the form of investments and funding is another factor fueling the PDX Model Market Size.

Moreover, as per the PDX Model Market forecast, the growing adoption of PDS models to study disease progression, owing to their ability to offer an accurate representation than other models. PDX models are used to test the efficiency of treatment in a more realistic environment and acknowledge the side effects of treatment, which is another factor propelling the market growth. However, the high cost associated with personalized PDX models and strict norms pertaining the use of animal models in cancer research might impede the market growth.

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Tumor type – Segment Analysis

Based on the tumor type, Respiratory Tumor Models segment is expected to grow at a higher CAGR during the forecast period in PDX models market share. This is attributed to the growing research-based activities in oncology as well as the increasing need to generate PDX models based on lung cancer due to rising cancer cases. For instance, in 2021, researchers of the Chinese Academy of Sciences (CAS) and their collaborators discovered the novel mechanism controlling TH9-mediated cancer immunotherapy and explained the underlying molecular mechanism. According to the World Health Organization (WHO), cancer is the second most leading cause of death globally and is responsible for an estimated 9.6 million deaths in 2018. Many companies are aiming to develop advanced products for the treatment of chronic disease in order to maintain their competitive advantage and penetrate new regional markets. Moreover, the increase in funding for companies involved in cancer research is another key factor influencing the global PDX models market.

Application – Segment Analysis

Based on the application, basic cancer research is projected to dominate the PDX models market share during the forecast period owing to an increase in the adoption of PDX models for basic cancer research. Basic cancer research is the description of cancer biology and exploring mechanisms that are involved prognosis or understanding of cancer. PDX models essentially provide important in-vivo and ex-vivo evidence to aid basic studies of cancer, including tumor characterization, tumorigenesis, and metastasis. Moreover, the increasing number of clinical trials is another vital factor driving this segment growth.

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Regional – Segment Analysis:

Based on the region, North America segment is expected to grow at a higher CAGR during the forecast period owing to a rise in funding initiatives and creating awareness among patients regarding personalized medicine. Patient-derived tumor xenografts are recognized as very relevant preclinical cancer models. According to American Cancer Society estimates, in 2018, there were 1,735,350 new cases of cancer detected in the US. Also, in 2018, the National Institute of Cancer expanded the storage of cancer research models to store more of such models. Hence, these are the key factors driving the PDX models market in North America.

Top Market Players

Various notable players operating in the market include JSR Corporation., WuXi AppTec, THE JACKSON LABORATORY, Charles River Laboratories., Oncodesign, Envigo, Pharmatest Services, Hera Biolabs., EPO Berlin-Buch GmbH, Xentech, among others. 

Key Developments:

• • In 2019, Charles River Laboratories., updated its online Tumor Model Compendium by adding 79 new patient-derived xenografts, ten new cell line-derived xenografts, and 36 new cell line models for several cancer types, including anal, colon, lung, and renal cancer, as well as leukemia and melanoma.
  • In 2019, Envigo acquired the assets of the research models business unit of Horizon Discovery Group plc.

Segments covered in the Report:

The global PDX Model market has been segmented on the basis of Type, Tumor type, Application, End-user and regions. Based on Type, the market is segmented into Mice Models and Rat Models. Based on Tumor type, the market is segmented into Gastrointestinal Tumor Models, Gynecological Tumor Models, Respiratory Tumor Models, Urological Tumor Models, Hematological Tumor Models and Others. Based on Application, the market is segmented into Preclinical Drug Development, Biomarker Analysis and Basic Cancer Research. Based on End-user the market is segmented into Pharmaceutical & Biotechnology Companies, Contract Research Organizations (CROs) and Academic & Research Institutions. 

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Market Segmentation

Global PDX Model Market by Type

• • Mice Models
  • Rat Models

Global PDX Model Market by Tumor type

• • Gastrointestinal Tumor Models
  • Gynecological Tumor Models
  • Respiratory Tumor Models
  • Urological Tumor Models
  • Hematological Tumor Models
  • Others

Global PDX Model Market by Application

• • Preclinical Drug Development
  • Biomarker Analysis
  • Basic Cancer Research

Global PDX Model Market by End-user

• • Pharmaceutical & Biotechnology Companies
  • Contract Research Organizations (CROs)
  • Academic & Research Institutions

Global PDX Model Market by Region

• • North America PDX Model Market (Option 1: As a part of the free 25% customization)

    • By Type
    • By Tumor type
    • By Application
    • By End-user
    • US Market All-Up
    • Canada Market All-Up

  • Europe PDX Model Market (Option 2: As a part of the free 25% customization)

    • By Type
    • By Tumor type
    • By Application
    • By End-user
    • UK Market All-Up
    • Germany Market All-Up
    • France Market All-Up
    • Spain Market All-Up
    • Rest of Europe Market All-Up

  • Asia-Pacific PDX Model Market (Option 3: As a part of the free 25% customization)

    • By Type
    • By Tumor type
    • By Application
    • By End-user
    • China Market All-Up
    • India Market All-Up
    • Japan Market All-Up
    • Rest of APAC Market All-Up

  • RoW PDX Model Market (Option 4: As a part of the free 25% customization)

    • By Type
    • By Tumor type
    • By Application
    • By End-user
    • Brazil Market All-Up
    • South Africa Market All-Up
    • Saudi Arabia Market All-Up
    • UAE Market All-Up
    • Rest of world (remaining countries of the LAMEA region) Market All-Up

Major Players Operating in the PDX Model (Option 5: As a part of the Free 25% Customization – Profiles of 5 Additional Companies of your Choice)

• • JSR Corporation.
  • WuXi AppTec
  • THE JACKSON LABORATORY
  • Charles River Laboratories.
  • Oncodesign
  • Envigo
  • Pharmatest Services
  • Hera Biolabs.
  • EPO Berlin-Buch GmbH
  • Xentech